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Variability of the subthalamic nucleus: The case for direct MRI guided targeting

Ashkan, K; Blomstedt, P; Zrinzo, L; Tisch, S; Yousry, T; Limousin-Dowsey, P; Hariz, MI; (2007) Variability of the subthalamic nucleus: The case for direct MRI guided targeting. British Journal of Neurosurgery , 21 (2) 197 - 200. 10.1080/02688690701272240.

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Abstract

Because of concerns about direct visualization of the subthalamic nucleus (STN) on magnetic resonance imaging ( MRI), many functional neurosurgeons continue to rely on atlas-based coordinates to reach this target. T2-weighted MRI does allow direct visualisation of the STN. In order to compare the coordinates of the target point within the visualised STN with those obtained from standard brain atlases, the preoperative stereotactic T2- weighted MRI used to implant 55 deep brain stimulation electrodes in the visualised STN of 29 consecutive patients with Parkinson's disease treated in two European centres were studied. The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus.

Type: Article
Title: Variability of the subthalamic nucleus: The case for direct MRI guided targeting
DOI: 10.1080/02688690701272240
Publisher version: http://dx.doi.org/10.1080/02688690701272240
Language: English
Keywords: Deep Brain Stimulation, Direct Targeting, Magnetic Resonance Imaging, Parkinson's Disease, Subthalamic Nucleus, Deep Brain-Stimulation, Parkinsons-Disease, Implantation, Electrodes
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/128071
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