Kemeny, DM; Vyas, B; Vukmanovic-Stejic, M; Thomas, MJ; Noble, A; Loh, LC; O'Connor, BJ; (1999) CD8(+) T cell subsets and chronic obstructive pulmonary disease. AM J RESP CRIT CARE , 160 (5) S33 - S37.
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COPD is a debilitating and progressive condition in which the airways become irreversibly obstructed and the lungs progressively damaged. Unlike asthma, we know little about the cells that initiate and drive this process. Research has shown that CD8(+) T cells are overrepresented in the lungs of patients with COPD and that they are inversely related to lung function. However, not all CD8(+) T cells are alike and subsets that make IFN-gamma but not IL-4 (Tc1), IL-4 but not IFN-gamma (Tc2) as well as those that make both (Tc0) have been described. This article focuses on the characteristics of CD8(+) T cell subsets and considers their potential contribution to chronic obstructive pulmonary disease (COPD).
|Title:||CD8(+) T cell subsets and chronic obstructive pulmonary disease|
|Keywords:||HOMOCYTOTROPIC ANTIBODY FORMATION, RESPIRATORY SYNCYTIAL VIRUS, BROWN-NORWAY RATS, IN-VIVO, MYCOBACTERIUM-TUBERCULOSIS, IGE RESPONSES, TH2 CYTOKINES, AIRWAY INFLAMMATION, BRONCHIAL BIOPSIES, INTERLEUKIN (IL)-4|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of) > Research Department of Immunology|
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