UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

C-reactive protein (+1444C > T) polymorphism influences CRP response following a moderate inflammatory stimulus

D'Aiuto, F; Casas, JP; Shah, T; Humphries, SE; Hingorani, AD; Tonetti, MS; (2005) C-reactive protein (+1444C > T) polymorphism influences CRP response following a moderate inflammatory stimulus. ATHEROSCLEROSIS , 179 (2) 413 - 417. 10.1016/j.atherosclerosis.2004.10.036.

Full text not available from this repository.

Abstract

Elevations in C-reactive protein (CRP) concentration are associated with an increased risk Of future coronary events in prospective Studies and it has been suggested that CRP Could be used to aid risk prediction. A + 1444C > T polymorphisrn in the CRP gene has been associated with differences in CRP concentration. We investigated the effect of this polyrnorphism on the CRP response to periodontal therapy, an intermediate inflammatory stimulus. Clinical parameters, CRP, and interleukin-6 (IL-6) concentrations were evaluated in 55 consecutive patients suffering from periodontitis at baseline. 1, 7 and 30 days after an intensive course of periodontal treatment. In a multivariate analysis individuals homozygous for the + 1444T allele showed higher CRP concentrations (day 1, 21.10 +/- 4.81 mg/L and day 7, 4.89 +/- 0.74 mg/L) compared with C-allele carriers (day 1, 12.37 +/- 1.61 mg/L and day 7,3.08 +/- 2.00 mg/L). This effect was independent of conventional cardiovascular risk factors and inflammatory factors known to affect CRP concentrations. CRP genotype may need to be considered when CRP values are used in coronary risk prediction. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: C-reactive protein (+1444C > T) polymorphism influences CRP response following a moderate inflammatory stimulus
DOI: 10.1016/j.atherosclerosis.2004.10.036
Keywords: periodontitis, inflammation, polymorphism, genetics, C-reactive protein, CORONARY-HEART-DISEASE, CARDIOVASCULAR-DISEASE, MARKERS, GENE, ASSOCIATION, PREVENTION, PREDICTION, RISK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
URI: http://discovery.ucl.ac.uk/id/eprint/127962
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item