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CYTOTOXICITY AND ANTIVIRAL ACTIVITY OF TRANSITION-METAL SALICYLATO COMPLEXES AND CRYSTAL-STRUCTURE OF BIS(DIISOPROPYLSALICYLATO)(1,10-PHENANTHROLINE)COPPER(II)

RANFORD, JD; SADLER, PJ; TOCHER, DA; (1993) CYTOTOXICITY AND ANTIVIRAL ACTIVITY OF TRANSITION-METAL SALICYLATO COMPLEXES AND CRYSTAL-STRUCTURE OF BIS(DIISOPROPYLSALICYLATO)(1,10-PHENANTHROLINE)COPPER(II). J CHEM SOC DALTON (22) 3393 - 3399.

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Abstract

Complexes of Cu(II), Fe(III), Co(II), Ni(II), Ti(IV) and Zn(II) with 3,5-disubstituted salicylates, and ternary complexes of Cu(II) containing substituted phenanthrolines have been prepared and characterised. The crystal structure of bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II), [Cu(phen)(Hdips)2], has been determined; Cu(II) is in a tetragonal co-ordination environment with in-plane bonds to 2 nitrogens from phen [Cu-N 2.014(4) angstrom] and 2 oxygens from the carboxylates of Hdips [Cu-01.951 (3) angstrom], with weaker off-axial bonds to carboxylate oxygens [Cu-O 2.557(3) angstrom]. The hydroxyl oxygen of Hdips is not co-ordinated. These complexes have been tested for antiviral and cytotoxic activity. Most are potently cytotoxic, especially [Cu(dmphen)(Hdips)2], where dmphen is 2,9-dimethylphenanthroline.

Type:Article
Title:CYTOTOXICITY AND ANTIVIRAL ACTIVITY OF TRANSITION-METAL SALICYLATO COMPLEXES AND CRYSTAL-STRUCTURE OF BIS(DIISOPROPYLSALICYLATO)(1,10-PHENANTHROLINE)COPPER(II)
Keywords:COPPER(II) COMPLEXES, TERNARY COMPLEXES, MONONUCLEAR, PERCHLORATE, BINUCLEAR, RATS, ACID
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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