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Task-related changes in cortical synchronization are spatially coincident with the hemodynamic response.

Singh, KD; Barnes, GR; Hillebrand, A; Forde, EME; Williams, AL; (2002) Task-related changes in cortical synchronization are spatially coincident with the hemodynamic response. Neuroimage , 16 (1) pp. 103-114. 10.1006/nimg.2001.1050.

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Abstract

Using group functional Magnetic Resonance Imaging (fMRI) and group Magnetoencephalography (MEG) we studied two cognitive paradigms: A language task involving covert letter fluency and a visual task involving biological motion direction discrimination. The MEG data were analyzed using an adaptive beam-former technique known as Synthetic Aperture Magnetometry (SAM), which provides continuous 3-D images of cortical power changes. These images were spatially normalized and averaged across subjects to provide a group SAM image in the same template space as the group fMRI data. The results show that frequency-specific, task-related changes in cortical synchronization, detected using MEG, match those areas of the brain showing an evoked cortical hemodynamic response with fMRI. The majority of these changes were event-related desynchronizations (ERDs) in the 5-10 Hz and 15-25 Hz frequency ranges. Our study demonstrates how SAM, spatial normalization, and intersubject averaging enable group MEG studies to be performed. SAM analysis also allows the MEG experiment to have exactly the same task design as the corresponding fMRI experiment. This new analysis framework represents an important advance in the use of MEG as a cognitive neuroimaging technique and also allows mutual cross-validation with fMRI.

Type: Article
Title: Task-related changes in cortical synchronization are spatially coincident with the hemodynamic response.
Location: United States
DOI: 10.1006/nimg.2001.1050
Keywords: Adult, Cerebral Cortex, Cerebrovascular Circulation, Cortical Synchronization, Discrimination (Psychology), Female, Humans, Magnetic Resonance Imaging, Magnetoencephalography, Male, Motion Perception, Nerve Net, Psychomotor Performance
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/127753
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