UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM AND SUSCEPTIBILITY TO PARKINSONS-DISEASE

SMITH, CAD; GOUGH, AC; LEIGH, PN; SUMMERS, BA; HARDING, AE; MARANGANORE, DM; STURMAN, SG; ... WOLF, CR; + view all (1992) DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM AND SUSCEPTIBILITY TO PARKINSONS-DISEASE. LANCET , 339 (8806) 1375 - 1377.

Full text not available from this repository.

Abstract

The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases.The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720 controls. Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2.54-fold (95% CI 1.51-4.28) increased risk of Parkinson's disease.Determination of CYP2D6 phenotype and genotype may help to identify those at greatest risk of Parkinson's disease and may also help to identify the environmental or metabolic agents involved in the pathogenesis of this disease.

Type: Article
Title: DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM AND SUSCEPTIBILITY TO PARKINSONS-DISEASE
Keywords: COMPLEX-I DEFICIENCY, POOR METABOLIZERS, CYP2D LOCUS, 4-HYDROXYLATION, PHENOTYPES, NEUROTOXIN, OXIDATION, DEFECT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/127536
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item