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Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse

Tsipouri, V; Curtin, JA; Nolan, PM; Vizor, L; Parsons, CA; Clapham, CM; Latham, ID; ... Gray, IC; + view all (2004) Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse. COMP FUNCT GENOM , 5 (2) 123 - 127. 10.1002/cfg.382. Gold open access

Abstract

Three mutant mice with pigmentation phenotypes were recovered from a genomewide random mouse chemical mutagenesis study. White toes (Whto; MGI:1861986), Belly spot and white toes (Bswt; MGI:2152776) and Dark footpads 2 (Dfp2; MGI:1861991) were identified following visual inspection of progeny from a male exposed to the point mutagen ethylnitrosourea (ENU). In order to rapidly localize the causative mutations, genome-wide linkage scans were performed on pooled DNA samples from backcross animals for each mutant line. Whto was mapped to proximal mouse chromosome (Mmu) 7 between Cen (the centromere) and D7Mit112 (8.0 cM from the centromere), Bswt was mapped to centric Mmul between D1MU214 (32.1 cM) and D1Mit480 (32.8 cM) and Dfp2 was mapped to proximal Mmu4 between Cen and D4Mit18 (5.2 cM). Whto, Bswt and Dfp2 may provide novel starting points in furthering the elucidation of genetic and biochemical pathways relevant to pigmentation and associated biological processes. Copyright (C) 2004 John Wiley Sons, Ltd.

Type: Article
Title: Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse
Open access status: An open access publication
DOI: 10.1002/cfg.382
Keywords: mouse, pigmentation mutant, ethylnitrosourea, mutagenesis, linkage, GENE-FUNCTION, MICE, MIGRATION, MUTATION, DISEASE
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/126731
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