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Genetic analysis of the cytoplasmic dynein subunit families

Pfister, KK; Shah, PR; Hummerich, H; Russ, A; Cotton, J; Annuar, AA; King, SM; (2006) Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genetics , 2 (1) , Article E1. 10.1371/journal.pgen.0020001. Green open access

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Abstract

Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of the subunits are encoded by at least two genes. Here we review current knowledge concerning the subunits, their interactions, and their functional roles as derived from biochemical and genetic analyses. We also carried out extensive database searches to look for new genes and to clarify anomalies in the databases. Our analysis documents evolutionary relationships among the dynein subunits of mammals and other model organisms, and sheds new light on the role of this diverse group of proteins, highlighting the existence of two cytoplasmic dynein complexes with distinct cellular roles.

Type: Article
Title: Genetic analysis of the cytoplasmic dynein subunit families
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pgen.0020001
Publisher version: http://dx.doi.org/10.1371/journal.pgen.0020001
Language: English
Additional information: © 2006 Pfister et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Light intermediate chain, outer arm dynein, mouse t-complex, retrograde intraflagellar transport, full-length human, caenorhabditis-elegans, heavy-chain, drosophila-melanogaster, axonal-transport, chlamydomonas-flagella
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/126636
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