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Brain serotonin transporter binding in former users of MDMA ('ecstasy')

Selvaraj, S; Hoshi, R; Bhagwagar, Z; Murthy, NV; Hinz, R; Cowen, P; ... Grasby, P; + view all (2009) Brain serotonin transporter binding in former users of MDMA ('ecstasy'). BRIT J PSYCHIAT , 194 (4) 355 - 359. 10.1192/bjp.bp.108.050344.

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Abstract

BackgroundAnimal experimental studies have prompted concerns that widespread use of 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') by young people may pose a major public health problem in terms of persistent serotonin neurotoxicity.AimsTo determine the status of brain serotonin neurons in a group of abstinent MDMA users.MethodWe assessed the integrity of brain serotonin neurons by measuring serotonin transporter (SERT) binding using positron emission tomography (PET) and [C-11]DASB in 12 former MDMA users, 9 polydrug users who had never taken MDMA and 19 controls who reported no history of illicit drug use.ResultsThere was no significant difference in the binding potential of [C-11]DASB between the groups in any of the brain regions examined.ConclusionsTo the extent that [C-11]DASB binding provides an index of the integrity of serotonin neurons, our findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans.

Type:Article
Title:Brain serotonin transporter binding in former users of MDMA ('ecstasy')
DOI:10.1192/bjp.bp.108.050344
Keywords:POSITRON-EMISSION-TOMOGRAPHY, 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA, PET, AVAILABILITY, CONSEQUENCES, RADIOLIGANDS, CONSUMPTION, COGNITION, ANIMALS, MONKEYS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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