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Transforming growth factor-beta and gamma-interferon have dual effects on growth of peripheral glia.

Eccleston, PA; Jessen, KR; Mirsky, R; (1989) Transforming growth factor-beta and gamma-interferon have dual effects on growth of peripheral glia. J Neurosci Res , 24 (4) pp. 524-530. 10.1002/jnr.490240410.

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Abstract

The influence of transforming growth factor-beta (TGF-beta) and gamma-interferon on DNA synthesis in Schwann cells and enteric glia in culture has been studied. TGF-beta stimulated the DNA synthesis of short-term (less than 2 weeks in culture) Schwann cells, whereas gamma-interferon was ineffective. The stimulatory effect of TGF-beta was additive to the stimulation of DNA synthesis due to axonal membrane fragments. In contrast to their effect on short-term Schwann cells, both TGF-beta and gamma-interferon inhibited DNA synthesis in enteric glial cells and in long-term (over 3 months in culture) Schwann cells. When short-term Schwann cells were stimulated to divide by axolemma or glial growth factor, gamma-interferon did not inhibit this enhanced DNA synthesis although it suppressed DNA synthesis induced by cAMP analogues. These results raise the possibility that TGF-beta and gamma-interferon might have a role in controlling glial proliferation during development and/or regeneration of the peripheral nervous system.

Type: Article
Title: Transforming growth factor-beta and gamma-interferon have dual effects on growth of peripheral glia.
Location: United States
DOI: 10.1002/jnr.490240410
Keywords: Animals, Cells, Cultured, DNA Replication, Interferon-gamma, Peripheral Nerves, Rats, Rats, Inbred Strains, Schwann Cells, Time Factors, Transforming Growth Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/126249
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