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Mismatch negativity in schizophrenia: a family study

Bramon, E; Croft, RJ; McDonald, C; Virdi, GK; Gruzelier, JG; Baldeweg, T; Sham, PC; ... Murray, RM; + view all (2004) Mismatch negativity in schizophrenia: a family study. SCHIZOPHR RES , 67 (1) 1 - 10. 10.1016/S0920-9964(03)00132-4.

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Abstract

Background: Mismatch negativity (MMN) is a measure of cortical activity that occurs in response to a change in auditory stimuli. We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls. Method: There are 25 schizophrenic patients, 37 of their unaffected first-degree relatives, and 20 unrelated controls that performed the MMN task. Linear regression with robust standard errors, and accounting for correlations within families, was employed to test for differences in MMN amplitude between the groups. Results: Patients had significantly smaller MMN amplitudes compared to both their unaffected relatives and controls at FZ (P < 0.01) and at F3 (P = 0.01), whereas relatives and controls did not differ at FZ or at F3. No differences were found between any of the groups at F4. Furthermore, we found no strong evidence that the MMN amplitude is a familial trait. Conclusions: Our results confirm that the MMN amplitude is reduced in schizophrenia. However, the MMN does not show a significant familial influence and is normal among the unaffected relatives. We conclude that while the MMN is abnormal in patients with schizophrenia, it is a weak or unreliable marker of vulnerability when applied to subclinical populations, and therefore is unlikely to be an endophenotype for the disorder. (C) 2003 Elsevier B.V. All rights reserved.

Type: Article
Title: Mismatch negativity in schizophrenia: a family study
DOI: 10.1016/S0920-9964(03)00132-4
Keywords: mismatch negativity, schizophrenia, family study, genetic vulnerability, biological marker and endophenotype, EVENT-RELATED POTENTIALS, AUDITORY SENSORY MEMORY, MAUDSLEY FAMILY, EYE TRACKING, RELATIVES, DYSFUNCTION, MMN, DURATION, STIMULI, BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/125780
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