Goede, AC;
Caplin, ME;
Winslet, MC;
(2003)
Carcinoid tumour of the appendix.
BRIT J SURG
, 90
(11)
1317 - 1322.
10.1002/bjs.4375.
Abstract
Background: Appendiceal carcinoid tumours are found in 0.3-0.9 per cent of patients undergoing appendicectomy. Controversy exists over the management following appendicectomy, especially with regard to the role of right hemicolectomy in patients with tumours smaller than 2 cm in diameter.Methods and results: The literature pertaining to the behaviour of appendiceal carcinoids was reviewed in order to formulate indications for right hemicolectomy. Metastatic disease from appendiceal carcinoids is a rare occurrence, but is more common when lesions are larger than 2 cm in diameter. The risk-benefit balance of right hemicolectomy needs to be better defined, and an improved understanding of tumour cell biology may aid prognostic accuracy and decision-making.Conclusion: There is limited evidence on which to base clear indications for right hemicolectomy in patients with a diagnosis of appendiceal carcinoid. Acceptable indications are carcinoids larger than 2 cm in size, any high-grade malignant carcinoid (including those with a high mitotic index), mesoappendiceal invasion, lesions at the base of the appendix with tumour-positive margins, and goblet cell adenocarcinoid tumours.
| Type: | Article |
|---|---|
| Title: | Carcinoid tumour of the appendix |
| DOI: | 10.1002/bjs.4375 |
| Keywords: | NEUROENDOCRINE TUMORS, CLASSIFICATION, METASTASES, PROGNOSIS, MIDGUT, TRACT |
| UCL classification: | UCL > School of Life and Medical Sciences UCL > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | http://discovery.ucl.ac.uk/id/eprint/125772 |
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