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The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation

Kilian, B; Mansukoski, H; Barbosa, FC; Ulrich, F; Tada, M; Heisenberg, CP; (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. MECH DEVELOP , 120 (4) 467 - 476. 10.1016/S0925-4773(03)00004-2.

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Abstract

Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

Type: Article
Title: The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
DOI: 10.1016/S0925-4773(03)00004-2
Keywords: Wnt signalling, convergent extension, gastrulation, zebrafish, CONVERGENT EXTENSION MOVEMENTS, CANONICAL WNT PATHWAY, XENOPUS-LAEVIS, EMBRYONIC-DEVELOPMENT, TAIL FORMATION, DANIO-RERIO, WILD-TYPE, EXPRESSION, VERTEBRATE, POLARITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/125754
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