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Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons

Guo, S; Wilson, SW; Cooke, S; Chitnis, AB; Driever, W; Rosenthal, A; (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. DEV BIOL , 208 (2) 473 - 487.

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Abstract

The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and adrenergic] neurons in the zebrafish, Danio rerio. The identified mutations constitute five complementation groups, motionless and foggy affect the number and differentiation state of hypothalamic DA, telencephalic DA, retinal DA, locus coeruleus (LC) NA, and sympathetic NA neurons. The too few mutation leads to a specific reduction in the number of hypothalamic DA neurons, no soul lacks arch-associated NA cells and has defects in pharyngeal arches, and soulless lacks both arch-associated and LC cell groups. Our analyses suggest that the genes defined by these mutations regulate different steps in the differentiation of multipotent CA. progenitors. They further reveal an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes. (C) 1999 Academic Press.

Type: Article
Title: Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons
Keywords: HYDROXYLASE-IMMUNOREACTIVE NEURONS, SONIC HEDGEHOG, LOCUS-COERULEUS, CAROTID-BODY, EMBRYONIC ZEBRAFISH, BRACHYDANIO-RERIO, FLOOR PLATE, CELLS, INDUCTION, BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/125597
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