Jagger, DJ; Ashmore, JF; (1998) A potassium current in guinea-pig outer hair cells activated by ion channel blocker DCDPC. NEUROREPORT , 9 (17) 3887 - 3891.
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FENAMATE compounds have been reported to inhibit ion channels in a number of tissues, including a nonselective cation channel in the mammalian outer hair cell (OHC). We have further investigated the effects of 3'-5-dichlorodiphenylamine-2-carboxylic acid (DCDPC) on OHC currents using the whole-cell configuration of the patch clamp technique. Extracellular application of 10 mu M DCDPC rapidly and reversibly activated an inward current at hyperpolarized potentials. The DCDPC-activated current appeared in the shorter OHCs from the basal turns of the cochlea. The reversal potential of the inward current was dependent on the external K+ ion concentration. An outwardly rectifying K+ current, found predominantly in OHCs from apical turns, was reversibly inhibited by DCDPC. These results suggest that DCDPC has a significant effect on OHC physiology at all tonotopic locations along the basilar membrane and so may have implications for cochlear function during fenamate intake. NeuroReport 9: 3887-3891 (C) 1998 Lippincott Williams & Wilkins.
|Title:||A potassium current in guinea-pig outer hair cells activated by ion channel blocker DCDPC|
|Keywords:||cochlea, fenamates, outer hair cells, potassium currents, NONSELECTIVE CATION CHANNEL, BASOLATERAL MEMBRANE, SMOOTH-MUSCLE, COCHLEA, EPITHELIUM, CALCIUM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology|
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