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Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors

Song, I; Kamboj, S; Xia, J; Dong, HL; Liao, DZ; Huganir, RL; (1998) Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors. NEURON , 21 (2) 393 - 400.

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Abstract

Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involved in the modulation of receptor function and clustering at excitatory synapses. In this paper, we have found that the N-ethylmaleimide-sensitive factor (NSF), a protein involved in membrane fusion events, specifically interacts with the C terminus of the GluR2 and GluR4c subunits of AMPA receptors in vitro and in vivo. Moreover, intracellular perfusion of neurons with a synthetic peptide that competes with the interaction of NSF and AMPA receptor subunits rapidly decreases the amplitude of miniature excitatory postsynaptic currents (mEPSCs), suggesting that NSF regulates AMPA receptor function.

Type: Article
Title: Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors
Keywords: GLUTAMATE RECEPTORS, RAT-BRAIN, SILENT SYNAPSES, PROTEIN, NEURONS, FUSION, LOCALIZATION, ACTIVATION, TRANSPORT, SUBTYPES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/125283
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