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Endothelial activation in patients with chronic disease

Saharay, M; Shields, DA; Georgiannos, SN; Porter, JB; Scurr, JH; Smith, PDC; (1998) Endothelial activation in patients with chronic disease. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY , 15 (4) 342 - 349.

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Abstract

Objectives: Leukocyte trapping due to leukocyte-endothelial activation has been implicated as the cause of lipodermatosclerosis and ulceration in patients with chronic venous disease. We investigated endothelial activity in normal controls and patients subjected to short-term venous hyper-tension.Methods: Twenty-five normal volunteers and 30 patients with chronic venoms disease divided into two groups: varicose veins with skin changes (LDS, n=15); and varicose veins without skin changes (VVs, n=15) were studied. Blood samples were taken from a foot vein before and after experimental venous hypertension. Plasma levels of ELAM-1 (endothelial leukocyte adhesion molecule-1), ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1), and von Willebrand factor (vWf) was measured by an ELISA.Results: There aas a significant rise in the plasma concentration of ELAM-1, ICAM-1 and VCAM-1 in patients and normal controls in response to venous hypertension. Basal levels of plasma VCAM-1 and vWf were higher in patients with LDS compared to patients with VVs. The magnitude of rise of VCAM-1 was greater in Patients with LDS compared to patients with VVs (p = 0.01, Mann-Whitney U-test). There was no difference in the basal levels or in the magnitude of change in plasma ICAM-1 and ELAM-1 between the two patient groups.Conclusion: Venous hypertension results in endothelial activation which may aid endothelial-leukocyte adhesion. Patients with LDS exhibit increased VCAM-1, which is a counterligand for receptors expressed by monocytes and lymphocytes signifying that these cells may be more important in the development of skirt changes.

Type: Article
Title: Endothelial activation in patients with chronic disease
Location: SOUTHAMPTON, ENGLAND
Keywords: venous-ulceration-aetiology, endothelial-adhesion molecules, leukocyte-activation, EXPERIMENTAL VENOUS HYPERTENSION, ADHESION MOLECULE-1 ICAM-1, VON-WILLEBRAND-FACTOR, LEUKOCYTE ADHESION, CIRCULATING ICAM-1, E-SELECTIN, CELL, ULCERATION, PLASMA, SKIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/125269
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