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Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

Pesnot, T; Jorgensen, R; Palcic, MM; Wagner, GK; (2010) Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. NAT CHEM BIOL , 6 (5) 321 - 323. 10.1038/nchembio.343.

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Abstract

Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous important biological processes. We have developed a new donor analog for galactosyltransferases that locks a representative target enzyme in a catalytically inactive conformation, thus almost completely abolishing sugar transfer. Results with other galactosyltransferases suggest that this unique mode of glycosyltransferase inhibition may also be generally applicable to other members of this important enzyme family.

Type:Article
Title:Structural and mechanistic basis for a new mode of glycosyltransferase inhibition
DOI:10.1038/nchembio.343
Keywords:CONFORMATIONAL-CHANGES, RATIONAL DESIGN, GLYCOSYLATION, SUBSTRATE
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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