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Heat shock protein 27 protects the heart against myocardial infarction

Efthymiou, CA; Mocanu, MM; de Belleroche, J; Wells, DJ; Latchmann, DS; Yellon, DM; (2004) Heat shock protein 27 protects the heart against myocardial infarction. BASIC RES CARDIOL , 99 (6) 392 - 394. 10.1007/s00395-004-0483-6.

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Abstract

Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.

Type:Article
Title:Heat shock protein 27 protects the heart against myocardial infarction
DOI:10.1007/s00395-004-0483-6
Keywords:heat shock protein 27, reperfusion injury, infarct size, mouse, SHOCK PROTEINS, STRESS-PROTEIN, MYOGENIC CELLS, VIRUS VECTOR, OVEREXPRESSION, ISCHEMIA, INJURY, EXPRESSION, APOPTOSIS, NEURONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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