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Delayed blood pressure recovery after psychological stress is associated with carotid intima-media thickness - Whitehall Psychobiology Study

Steptoe, A; Donald, AE; O'Donnell, K; Marmot, M; Deanfield, JE; (2006) Delayed blood pressure recovery after psychological stress is associated with carotid intima-media thickness - Whitehall Psychobiology Study. Arteriosclerosis, Thrombosis, and Vascular Biology , 26 (11) 2547 - 2551. 10.1161/01.ATV.0000242792.93486.0d.

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Abstract

Objective - Delayed blood pressure ( BP) recovery after psychological stress is associated with low socioeconomic status ( SES) and prospectively with increases in clinic BP. We tested whether poststress BP recovery was related to carotid atherosclerosis.Methods and Results - Psychophysiological stress testing was performed with a healthy subgroup of the Whitehall II epidemiological cohort, and recovery systolic BP was monitored 40 to 45 minutes after stressful behavioral tasks. Carotid ultrasound scanning was conducted on 136 men and women ( aged 55.3 +/- 2.7 years) 3 years after stress testing. Participants were divided into those whose systolic BP had returned to baseline in the recovery period ( adequate recovery, n = 37), and those whose BP remained elevated ( delayed recovery, n = 99). Systolic BP stress responses did not differ in the 2 groups. Carotid intima-media thickness ( IMT) was associated with delayed recovery in lower SES ( means 0.78 versus 0.65 mm) but not higher SES participants ( means 0.75 versus 0.74 mm) after adjustment for age, gender, baseline systolic BP, and resting BP, smoking, body mass and fasting cholesterol at the time of ultrasound scanning ( P = 0.010).Conclusions - Variations in poststress recovery reflect dysfunction of biological regulatory processes, and may partly mediate psychosocial influences on cardiovascular disease.

Type: Article
Title: Delayed blood pressure recovery after psychological stress is associated with carotid intima-media thickness - Whitehall Psychobiology Study
DOI: 10.1161/01.ATV.0000242792.93486.0d
Publisher version: http://dx.doi.org/10.1161/01.ATV.0000242792.93486....
Language: English
Keywords: Atherosclerosis, blood pressure, recovery, socioeconomic status, stress, aged finnish men, socioeconomic-status, cardiovascular recovery, atherosclerosis, responses, disease, progression, risk, hypertension, increases
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: http://discovery.ucl.ac.uk/id/eprint/124861
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