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Pregnancy reduces noradrenaline but not neuropeptide levels in the uterine artery of the guinea-pig.

Mione, MC; Cavanagh, JF; Lincoln, J; Milner, P; Burnstock, G; (1990) Pregnancy reduces noradrenaline but not neuropeptide levels in the uterine artery of the guinea-pig. Cell Tissue Res , 259 (3) pp. 503-509.

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Abstract

Using histochemical, immunohistochemical and biochemical techniques, noradrenaline-, neuropeptide Y-, vasoactive intestinal polypeptide-, substance P- and calcitonin gene-related peptide-containing nerve fibres were studied in the uterine artery of virgin, progesterone-treated and pregnant guinea-pigs. Morphological changes following hormone treatment or in pregnancy were also evaluated in a quantitative study on semithin sections of the uterine artery. In late pregnancy, the number of noradrenaline-containing nerve fibres, which formed the densest plexus in virgin animals, was significantly decreased, a finding supported by a significant reduction in noradrenaline levels. This reduction was not mimicked by systemic progesterone treatment. In contrast, the innervation of the uterine artery by neuropeptide Y-containing nerve fibres was increased in pregnancy, while the other peptidergic nerves and peptide levels were unchanged after progesterone treatment and in pregnancy. These changes led to a predominance of innervation by neuropeptide Y- rather than noradrenaline-containing nerve fibres in late pregnancy. No morphological changes were detected following progesterone treatment, but pregnancy led to a marked increase in the cross-sectional area of the vessel accompanied by an increase in the thickness of the media.

Type: Article
Title: Pregnancy reduces noradrenaline but not neuropeptide levels in the uterine artery of the guinea-pig.
Location: Germany
Keywords: Animals, Arteries, Calcitonin Gene-Related Peptide, Female, Guinea Pigs, Nerve Fibers, Neuropeptide Y, Neuropeptides, Norepinephrine, Pregnancy, Pregnancy, Animal, Progesterone, Substance P, Uterus, Vasoactive Intestinal Peptide
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/124498
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