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The HIF pathway in cancer

Maxwell, PH; (2005) The HIF pathway in cancer. SEMIN CELL DEV BIOL , 16 (4-5) 523 - 530. 10.1016/j.semcdb.2005.03.001.

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Abstract

The transcription factor hypoxia-inducible factor-1 (HIF) is commonly activated in cancer. This has major effects on gene expression, and is important in tumor angiogenesis. Besides being activated by low oxygen, genetic events in cancer contribute to activating HIF. Most striking is that loss of function of the VHL tumour suppressor protein results in constitutive activation of the HIF pathway. An important aim is to define the contribution of HIF activation to the evolution of different cancers, and its potential as a therapeutic target. (c) 2005 Elsevier Ltd. All rights reserved.

Type:Article
Title:The HIF pathway in cancer
DOI:10.1016/j.semcdb.2005.03.001
Keywords:HIF, VHL, hypoxia, cancer, angiogenesis, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, LINDAU TUMOR-SUPPRESSOR, PROLYL HYDROXYLATION, FIBRONECTIN MATRIX, FACTOR 1-ALPHA, REGULATE HIF, CELL-DEATH, GROWTH, GENE, HIF-1-ALPHA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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