Stumpf, MPH; Wilkinson-Herbots, HM; (2004) Allelic histories: positive selection on a HIV-resistance allele. TRENDS ECOL EVOL , 19 (4) 166 - 168. 10.1016/j.tree.2004.02.001.
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The CCR5-Delta32 allele crucially determines the course of HIV infection and appears to be highly protective against the disease. Population genetic studies suggest that the allele has been under positive selection in Europe in the past. In a recent paper, Alison Gallvani and Montgomery Slatkin collate the available evidence and use a mathematical model to strongly suggest that smallpox could have exerted sufficient selection pressure to explain the distribution of the allele across Europe. This is a beautiful example of the power of mathematical models in evolutionary genetics.
|Title:||Allelic histories: positive selection on a HIV-resistance allele|
|Keywords:||NATURAL-SELECTION, EPIDEMICS, ORIGIN|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science|
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