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The JAK2(V617F) mutation and thrombosis

Austin, SK; Lambert, JR; (2008) The JAK2(V617F) mutation and thrombosis. BRIT J HAEMATOL , 143 (3) 307 - 320. 10.1111/j.1365-2141.2008.07258.x.

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Abstract

Since the discovery of the JAK2(V617F) mutation, the clinical and pathological consequences of this acquired defect have been extensively investigated to determine whether its presence characterises a distinct subgroup of myeloproliferative disorders (MPD). MPD management remains highly dependent on the patient's thrombotic risk. Whether the presence of the JAK2(V617F) mutation modifies the thrombotic risk is currently contentious, although there is increasing clinical evidence to suggest that the mutation may be variably associated with thrombosis. These observations are further supported by laboratory parameters which suggest that the JAK2(V617F) mutation may confer increased activation of leucocytes and platelets in MPD. The role of screening for the JAK2(V617F) mutation in patients presenting with thrombosis without overt MPD is unclear, but appears justified in cases of idiopathic splanchnic vein thrombosis.

Type: Article
Title: The JAK2(V617F) mutation and thrombosis
DOI: 10.1111/j.1365-2141.2008.07258.x
Keywords: JAK2(V617F), thrombosis, splanchnic vein thrombosis, polycythaemia rubra vera, essential thrombocythaemia, JAK2 V617F MUTATION, SPLANCHNIC VEIN-THROMBOSIS, BUDD-CHIARI-SYNDROME, CHRONIC MYELOPROLIFERATIVE DISORDERS, ERYTHROID COLONY FORMATION, TISSUE FACTOR EXPRESSION, TYROSINE KINASE JAK2, ESSENTIAL THROMBOCYTHEMIA, POLYCYTHEMIA-VERA, RISK-FACTORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School
URI: http://discovery.ucl.ac.uk/id/eprint/123926
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