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Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials

Ishikawa, S; Matsunaga, K; Nakanishi, R; Kawahira, K; Murayama, N; Tsuji, S; Huang, YZ; (2007) Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials. CLIN NEUROPHYSIOL , 118 (5) 1033 - 1043. 10.1016/j.clinph.2007.02.003.

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Abstract

Objective: To study the after-effect of theta burst stimulation (TBS) over the left sensorimotor cortex on the size of somatosensory as well as motor evoked potentials evoked from both hemispheres in healthy human subjects.Methods: We used a continuous TBS paradigm for 40 s (600 pulses) in which a burst of 3 transcranial magnetic stimuli at 50 Hz is repeated at 5 Hz [Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron 2005;45:201-6]. Somatosensory evoked potentials (SEPs) following electrical stimulation of right or left median nerve and motor evoked potentials (MEPs) in the right or left first dorsal interosseous (FDI) muscles were recorded before and after TBS over the left motor cortex (M1) or a point 2 cm. posterior to left M1.Results: Amplitudes of P25/N33 (parietal components) following right median nerve stimulation were significantly increased for at least 53 min after TBS over the left M1, whereas this component was suppressed for 13 min after TBS over a point 2 cm posterior. MEPs in right as well as left FDI muscles were suppressed with a similar time course after TBS over the left M1.Conclusions: A single-session of TBS over the sensorimotor cortex can induce a short-lasting change in the size of ipsilateral cortical components of SEPs as well as MEPs evoked from both hemispheres.Significance: TBS is an interventional tool that can induce rapid reorganization within cortical somatosensory as well as motor networks in humans. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials
DOI: 10.1016/j.clinph.2007.02.003
Keywords: theta burst stimulation, transcranial magnetic stimulation, motor evoked potentials, somatosensory evoked potentials, neuroplasticity, cortical excitability, TRANSCRANIAL MAGNETIC STIMULATION, LOW-FREQUENCY RTMS, INTERHEMISPHERIC FACILITATION, CORTICAL EXCITABILITY, CONTRALATERAL MOTOR, BRAIN-STIMULATION, MEDIAN NERVE, HAND-AREA, PLASTICITY, PARIETAL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/123489
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