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Two-Compartment Models of the Diffusion MR Signal in Brain White Matter

Panagiotaki, E; Fonteijn, H; Siow, B; Hall, MG; Price, A; Lythgoe, MF; Alexander, DC; (2009) Two-Compartment Models of the Diffusion MR Signal in Brain White Matter. In: Yang, GZ and Hawkes, D and Rueckert, D and Nobel, A and Taylor, C, (eds.) MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2009, PT I, PROCEEDINGS. (pp. 329 - 336). SPRINGER-VERLAG BERLIN

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Abstract

This study aims to the minimum requirements for an accurate model of the diffusion MR, signal in matter of the brain. We construct a hierarchy of two-compartment, models of white matter from combinations of simple models for die intra and extracellular spaces. We devise a, new diffusion MRI protocol that provides measurements with a wide range of parameters for diffusion sensitization both parallel and perpendicular to white matter fibres. We use the protocol to acquire data from a fixed rat brain, which allows us to fit, study and compare the different models. The results show that, models which incorporate pore size describe the measurements most, accurately. The best fit comes from combining a full diffusion tensor (DT) model of the extra-cellular space with a cylindrical intra-cellular component.

Type:Proceedings paper
Title:Two-Compartment Models of the Diffusion MR Signal in Brain White Matter
Event:12th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI2009)
Location:Imperial Coll, London, ENGLAND
Dates:2009-09-20 - 2009-09-24
ISBN-13:978-3-642-04267-6
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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