Tress, ML and Martelli, PL and Frankish, A and Reeves, GA and Wesselink, JJ and Yeats, C and Olason, PI and Albrecht, M and Hegyi, H and Giorgetti, A and Raimondo, D and Lagarde, J and Laskowski, RA and Lopez, G and Sadowski, MI and Watson, JD and Fariselli, P and Rossi, I and Nagy, A and Kai, W and Storling, Z and Orsini, M and Assenov, Y and Blankenburgh, H and Huthmacher, C and Ramirez, F and Schlicker, A and Denoued, F and Jones, P and Kerrien, S and Orchard, S and Antonarakis, SE and Reymond, A and Birney, E and Brunak, S and Casadio, R and Guigo, R and Harrow, J and Hermjakob, H and Jones, DT and Lengauer, T and Orengo, CA and Patthy, L and Thornton, JM and Tramontano, A and Valencia, A (2007) The implications of alternative splicing in the ENCODE protein complement. P NATL ACAD SCI USA , 104 (13) 5495 - 5500. 10.1073/pnas.0700800104.
Full text not available from this repository.
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.
|Title:||The implications of alternative splicing in the ENCODE protein complement|
|Keywords:||function, human, isoforms, splice, structure, HOMOPHILIC BINDING, MESSENGER-RNA, DNA-SEQUENCE, GENOME-WIDE, HUMAN IL-4, VARIANT, CELL, PREDICTION, GENES, IDENTIFICATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology|
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
Archive Staff Only: edit this record