Scott, KM and Abhinav, K and Stanton, BR and Johnston, C and Turner, MR and Ampong, MA and Sakel, M and Orrell, RW and Howard, R and Shaw, CE and Leigh, PN and Al-Chalabi, A (2009) Geographical Clustering of Amyotrophic Lateral Sclerosis in South-East England: A Population Study. NEUROEPIDEMIOLOGY , 32 (2) 81 - 88. 10.1159/000177032.
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Background: Amyotrophic lateral sclerosis (ALS) is a degenerative disease of motor neurons that causes progressive paralysis and eventually results in death from respiratory failure. Environmental factors that trigger ALS might result in a pattern of geographical clustering of cases. We tested this hypothesis using the South-East England ALS population register, which covers south-east London, Kent and parts of neighbouring counties. Methods: The register's catchment area was divided into postcode districts and sectors. The expected rates of ALS (adjusted for age and sex) were compared with the observed rates using a standardised residuals method and the SaTScan programme. Results: There were 406 cases of ALS identified in the catchment area during the study period. Four of the 126 postcode districts, all in Greater London, had residuals >2.5 SDs from the mean. Similarly, there were 15 postcode sectors (out of 420) that had residuals >1.96 SDs from the mean. Nine of these were in Greater London. SaTScan identified an area that had a 5.61-km radius in which the relative risk of ALS was 1.70 (p = 0.012). This area overlapped with the postcode districts and some of the sectors identified using the residuals method. Conclusions: These findings suggest an excess of ALS cases in some postcode districts in south-east England. Copyright (C) 2008 S. Karger AG, Basel
|Title:||Geographical Clustering of Amyotrophic Lateral Sclerosis in South-East England: A Population Study|
|Keywords:||Amyotrophic lateral sclerosis, Motor neuron disease, Geographical distribution, Population study, MOTOR-NEURON DISEASE, ALS, DEMENTIA, MUTATION, SMOKING, RISK|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical Neuroscience|
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