Skipworth, J; Foster, J; Raptis, D; Hughes, F; (2009) The effect of preoperative weight loss and body mass index on postoperative outcome in patients with esophagogastric carcinoma. DIS ESOPHAGUS , 22 (7) 559 - 563. 10.1111/j.1442-2050.2009.00939.x.
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P>Studies have shown that weight loss is associated with adverse outcomes in all treatment modalities for esophagogastric carcinoma. Because of the increased prevalence of obesity and the effectiveness of perioperative nutrition, a number of patients are now obese or have normal body mass index (BMI) at the time of treatment. We investigated the relationship between weight loss, BMI, and outcome of surgery for patients with esophagogastric carcinoma. Data were collected over a 38-month period for all patients diagnosed with operable esophagogastric cancer at two UK centers. All patients underwent resection by a single Consultant Upper Gastrointestinal Surgeon and the use of perioperative jejunal feeding was universal. Ninety-three patients (57 male) underwent esophagogastric resection; 48 had no preoperative weight loss (34 with a BMI > 25 and 14 with a BMI < 25). Forty-five patients had preoperative weight loss (20 with BMI > 25 and 25 with BMI < 25). There was no significant difference in complication rates, median hospital stay, or mortality between the four groups. A significantly higher number of patients displaying preoperative weight loss were found to have stage III disease, but difference in survival of up to 3 years did not reach statistical significance on multivariate analysis. Preoperative weight loss and low BMI did not significantly influence the complication rate, perioperative mortality rate, length of hospital stay, or short-term prognosis. We conclude that preoperative weight loss can not be reliably used as an independent predictor of poor outcome in patients undergoing surgery for esophagogastric carcinoma. However, patients with preoperative weight loss and low BMI are more likely to have advanced disease.
|Title:||The effect of preoperative weight loss and body mass index on postoperative outcome in patients with esophagogastric carcinoma|
|Keywords:||esophageal surgery, postoperative complications, preoperative nutritional status, prognosis, ADVANCED GASTROINTESTINAL CANCER, RESTING ENERGY-EXPENDITURE, NUTRITIONAL-STATUS, DEFINITIVE CHEMORADIOTHERAPY, ESOPHAGEAL-CARCINOMA, DIETARY-INTAKE, SERUM-ALBUMIN, SURVIVAL, SURGERY, RISK|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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