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CD4: a co-receptor in the immune response and HIV infection.

Bowers, K; Pitcher, C; Marsh, M; (1997) CD4: a co-receptor in the immune response and HIV infection. Int J Biochem Cell Biol , 29 (6) 871 - 875.

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Abstract

CD4 is a transmembrane glycoprotein of the immunoglobulin superfamily, expressed on developing thymocytes, major histocompatibility class II (class II MHC) restricted mature T lymphocytes and, in humans, on cells of the macrophage/monocyte lineage. On lymphoid cells, CD4 plays a critical role during thymocyte ontogeny and in the function of mature T cells. CD4 binds to non-polymorphic regions of class II MHC acting as a co-receptor for the T-cell antigen receptor (TCR). It increases avidity between thymocytes and antigen-presenting cells and contributes directly to signal transduction through association with the Src-like protein tyrosine kinase p56lck. Its precise role on monocytes and macrophages is unclear. CD4 is also a co-receptor for the human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV). Clinically, CD4 antibodies may be used to achieve immunological tolerance to grafts and transplants.

Type:Article
Title:CD4: a co-receptor in the immune response and HIV infection.
Location:ENGLAND
Language:English
Keywords:Animals, Antibodies, Monoclonal, Antibody Formation, Antigens, CD4, HIV Antigens, HIV Infections, Humans, Mice, Peptide Biosynthesis, Protein Structure, Tertiary, Rats, Structure-Activity Relationship
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology

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