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Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat

Aitken, WAE; Chisholm, AWAH; Duncan, AW; Harper, MJ; Humphries, SE; Mann, JI; ... Williams, SM; + view all (2006) Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat. NUTR METAB CARDIOVAS , 16 (5) 353 - 363. 10.1016/j.numecd.2005.06.007.

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Abstract

Background and aims: Some individuals respond to a greater extent than others to changes in dietary fat and cholesterol even when dietary intake is consistent. A prospective study has been undertaken in which two groups of individuals according to cholesteryl ester transfer protein (CETP) genotype were compared in terms of plasma lipid response to attering the nature of dietary fat in a free-living situation.Methods and results: Following genotyping, 35 individuals with the CETP Taq1 B1B1 genotype were paired with age and sex-matched individuals with one or two CETP B2 alleles, to undertake a single crossover trial with a diet high in saturated fat and a diet high in polyunsaturated fat. There was no washout period between the two 4-week phases. Plasma lipoproteins were measured at the beginning and end of each phase. The difference (95% Cl) in plasma LDL-cholesterol concentration at the end of the PUFA and SAFA diets was 0.95 (0.71, 1.19) mmol/l in the CETP B1B1 group and 0.80 (0.57,1.04) mmol/l in the group with at least one CETP B2 allete. The dietary induced changes in the two genotype groups were not significantly different (p = 0. 38) from each other. Comparable results were observed for plasma total cholesterol. The high PUFA and SAFA diets did not significantly alter plasma HDL concentration in either of the CETP genotype groups. Response was also similar according to apolipoprotein E genotype (E3E3 vs E4+) and lipoprotein lipase genotype (S447X).Conclusions: The results of this study do not support previous studies in which CETP genotype predicted plasma LDL-cholesterot response to diet. CETP genotype does not significantly affect the change in plasma total and LDL-cholesterol concentrations that occur when altering the nature of dietary fat. These data suggest that the influence of genetic factors on total and LDL-choLesterol may be relatively small in comparison with the effect of dietary manipulation. (c) 2005 Elsevier B.V. All rights reserved.

Type:Article
Title:Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat
DOI:10.1016/j.numecd.2005.06.007
Keywords:CETP, LPL S447X, APOE genotypes, dietary fat, compliance, plasma cholesterol, DENSITY-LIPOPROTEIN-CHOLESTEROL, APOLIPOPROTEIN-E POLYMORPHISM, BODY-MASS INDEX, SERUM-CHOLESTEROL, LIPID RESPONSE, CANDIDATE GENES, SATURATED FAT, LOWERING DIET, E PHENOTYPE, E GENOTYPE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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