UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease

Wong, WMR; Stephens, JW; Acharya, J; Hurel, SJ; Humphries, SE; Talmud, PJ; (2004) The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. J LIPID RES , 45 (8) 1565 - 1571. 10.1194/jlr.M400130. Gold open access

Abstract

Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe(-/-) mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro. In humans, there is an inverse relationship between apoA-IV levels and risk of coronary heart disease (CHD). Furthermore, the APOA4 T347S rare allele has been associated with increased risk of CHD and reduced apoA-fV levels. Reduced total antioxidant status (TAOS) due to increased oxidative stress is implicated in the process of atherogenesis. Thus, this study aimed to examine the association between the APOA4 T347S variant and TAOS in diabetic patients with (n = 196) or without (n = 509) cardiovascular disease (CVD). A higher percentage of CVD patients were present in the lowest quartile of TAOS, compared with the rest (P = 0.04). Overall, there was no association between genotype and TAOS. However, in patients with CVD, homozygotes for the S347 allele had significantly lower TAOS compared with TT and TS subjects (31.2 +/- 9.89% and 42.5 +/- 13.04% TAOS, respectively; P = 0.0024), an effect that was not seen in the patients without CVD.square This study offers direct support for an antioxidant capacity of apoA-IV, thus providing some explanation for the antiatherogenic role of apoA-IV and the higher CVD risk in S347 homozygotes.-Wong, W-m. R., J. W. Stephens, J. Acharya, S. J. Hurel, S. E. Humphries, and P. J. Talmud. The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease.

Type:Article
Title:The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease
Open access status:An open access publication
DOI:10.1194/jlr.M400130
Keywords:apolipoprotein A-IV, association study, oxidized low density lipoprotein, total antioxidant status, APOLIPOPROTEIN-A-IV, CORONARY-HEART-DISEASE, OXIDATIVE STRESS, CHOLESTEROL ACYLTRANSFERASE, DENSITY-LIPOPROTEINS, GENE-CLUSTER, ACTIVATION, ATHEROSCLEROSIS, PROTEIN, CELLS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

Archive Staff Only: edit this record