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A NEW COMPONENT OF THE TRANSCRIPTION FACTOR-DRTF1/E2F

GIRLING, R; PARTRIDGE, JF; BANDARA, LR; BURDEN, N; TOTTY, NF; HSUAN, JJ; LATHANGUE, NB; (1993) A NEW COMPONENT OF THE TRANSCRIPTION FACTOR-DRTF1/E2F. NATURE , 362 (6415) 83 - 87.

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Abstract

TRANSCRIPTION factor DRTF1/E2F coordinates events in the cell cycle with transcription by its cyclical interactions with important regulators of cellular proliferation like the retinoblastoma tumour-suppressor gene product (Rb) and the Rb-related protein, p107 (refs 1-8). DRTF1/E2F binding sites occur in the control regions of genes involved in proliferation9,10, and both Rb and p107 repress the capacity of DRTF1/E2F to activate transcription (refs 11, 12; M. Zamanian and N.B.L.T., manuscript submitted). Mutant Rb proteins isolated from tumour cells are unable to bind DRTF1/E2F (refs 11-13), and certain viral oncoproteins, such as adenovirus E1A, sequester Rb and p107 in order to free active DRTF1/E2F (refs 5, 11, 12, 14, 15). Here we report the isolation of a complementary DNA encoding DRTF1-polypeptide-1 (DP-1), a major sequence-specific binding protein that is present in DRTF1/E2F, including Rb- and p107-associated DRTF1/E2F. The DNA-binding domain of DP-1 contains a region that resembles that of E2F-1 (refs 16, 17), and recognizes the same sequence. DRTF1/E2F thus appears to contain at least two sequence-specific DNA-binding proteins.

Type:Article
Title:A NEW COMPONENT OF THE TRANSCRIPTION FACTOR-DRTF1/E2F
Keywords:RETINOBLASTOMA GENE-PRODUCT, CARCINOMA STEM-CELLS, T-ANTIGEN, CYCLIN-A, PROTEIN, DIFFERENTIATION, BINDING, TRANSACTIVATION, ADENOVIRUS-E1A, REGIONS

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