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Regional differences in the severity of Lewy body pathology across the olfactory cortex

Silveira-Moriyama, L; Holton, JL; Kingsbury, A; Ayling, H; Petrie, A; Sterlacci, W; ... Revesz, T; + view all (2009) Regional differences in the severity of Lewy body pathology across the olfactory cortex. NEUROSCI LETT , 453 (2) 77 - 80. 10.1016/j.neulet.2009.02.006.

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Abstract

We studied alpha-synuclein pathology in the rhinencephalon of ten cases of Parkinson's disease (PD) and twelve neurologically normal controls, of which seven had incidental Lewy bodies in the substantia nigra at autopsy and five had no pathological evidence of neurological disease. In all PD and incidental Lewy bodies cases, alpha-synuclein pathology was found in all five subregions of the primary olfactory cortex that were sampled, and amongst them the pathology was significantly more severe in the temporal division of the piriform cortex than in the frontal division of the piriform cortex, olfactory tubercle or anterior portions of the entorhinal cortex. The orbitofrontal cortex, which is an area of projection from the primary olfactory cortex, was affected in some cases but overall the alpha-synuclein pathology was less severe in this area than in the primary olfactory cortex. Because different areas of the rhinencephalon are likely to play different roles in olfaction and our data indicate a differential involvement by alpha-synuclein deposition of structures implicated in smell, future prospective studies investigating the pathophysiological basis of hyposmia in PD should consider to examine the areas of primary olfactory cortex separately. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:Regional differences in the severity of Lewy body pathology across the olfactory cortex
DOI:10.1016/j.neulet.2009.02.006
Keywords:Parkinson's disease, Incidental Lewy body disease, Rhinencephalon, Primary olfactory cortex, Piriform cortex, SPORADIC PARKINSONS-DISEASE, ALPHA-SYNUCLEIN PATHOLOGY, TEMPORAL-LOBE EPILEPSY, PIRIFORM CORTEX, NERVOUS-SYSTEM, BULB, DYSFUNCTION, LOBECTOMY, DIAGNOSIS, BRAIN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute

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