Adeyemo, D; Imtiaz, F; Toffa, S; Lowdell, M; Wickremasinghe, RG; Winslet, M; (2001) Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein. CANCER LETT , 164 (1) 77 - 84.
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5 Fluorouracil (5 FU), the most effective systemic chemotherapeutic agent in the management of advanced colorectal carcinoma acts by inducing apoptosis. Response rates, approximately 20% is improved by folinic acid. This study investigates similar modulation of 5 FU-induced apoptosis by oxidant quenching. A five-fold reduction of intracellular oxidant levels by antioxidants N-acetylcysteine and vitamin E did not induce apoptosis, it however augmented pro-apoptotic bax protein expression, and apoptotic response to a non-toxic dose of 5 EU in the colorectal cancer cell lines cole 201 and cole 205. This suggests that reduction of intracellular levels of reactive oxygen species enhance susceptibility to 5 FU (apoptotic stimuli) by augmentation of bax expression. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
|Title:||Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein|
|Keywords:||apoptosis, bax, colorectal neoplasms, reactive oxygen species, antioxidant, BCL-2 GENE FAMILY, COLORECTAL-CANCER, CYTOCHROME-C, REACTIVE OXYGEN, CHEMOTHERAPEUTIC-AGENTS, HYDROGEN-PEROXIDE, APOPTOSIS, MITOCHONDRIA, SURVIVAL, RELEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Haematology
UCL > School of Life and Medical Sciences > SLMS Planning and Performance Unit > SLMS Research Support Centre > Platform Technologies
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