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Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL60 promyelocytic leukaemia cell line

Mengubas, K; Riordan, FA; Hoffbrand, AV; Wickremasinghe, RG; (1996) Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL60 promyelocytic leukaemia cell line. FEBS LETT , 394 (3) 356 - 360.

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Abstract

The bcl-2 protein suppresses apoptosis and the bax protein opposes the cytoprotective effect of bcl-2, A decrease in bcl-2 levels has been implicated in the induction of apoptosis during the terminal differentiation of HL60 myeloid leukaemia cells. We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA), Decreased bcl-2 protein expression in induced cells was associated with downregulation of its mRNA. By contrast, the decrease in bax occurred by a post-transcriptional mechanism. Co-ordinate downregulation of bcl-2 and bax proteins may fine-tune the induction of apoptosis during cellular differentiation.

Type: Article
Title: Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL60 promyelocytic leukaemia cell line
Keywords: apoptosis, proto-oncogene protein, cell differentiation, myeloid leukemia, HL60 cell, MYELOID-LEUKEMIA CELLS, RETINOIC ACID, INHIBITS APOPTOSIS, DNA FRAGMENTATION, 2ND MESSENGERS, DEATH, PROTEIN, TRANSCRIPTS, HOMOLOG, CLONING
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/121870
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