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The fast activating potassium current, I-K,I-f, in guinea-pig inner hair cells is regulated by protein kinase A

Jagger, DJ; Ashmore, JF; (1999) The fast activating potassium current, I-K,I-f, in guinea-pig inner hair cells is regulated by protein kinase A. NEUROSCI LETT , 263 (2-3) 145 - 148.

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Abstract

The mammalian inner hair cell (IHC) responds to displacements produced in the cochlea by sound by releasing neurotransmitter from its basal pole. A basolateral fast activating potassium current, called I-K,I-f, allows IHCs to act as sensory cells at high frequencies by shortening the membrane time constant. This current is co-expressed with a slower activating current, I-K,I-s We have studied the intracellular regulation of IHC currents using the whole-cell patch clamp technique in conjunction with agents that influence the function of protein kinase A (PKA). Bath applied 8-Bromo-cAMP, an activator of PKA, increased the amplitude of outwardly rectifying currents and shortened the exponential time constant of activation. Following blockade of I-K,I-s by intracellular 4-AP, I-K,I-f could be reduced in amplitude by H-89, an inhibitor of PKA. Our results suggest that PKA regulates I-K,I-f and so shapes the frequency response of IHCs. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Type: Article
Title: The fast activating potassium current, I-K,I-f, in guinea-pig inner hair cells is regulated by protein kinase A
Keywords: inner hair cell, potassium current, cochlea, guinea-pig, patch clamp, protein kinase A, COCHLEA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/121764
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