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The development of activity evoked by fine diameter cutaneous fibres in the spinal cord of the newborn rat.

Fitzgerald, M; (1988) The development of activity evoked by fine diameter cutaneous fibres in the spinal cord of the newborn rat. Neurosci Lett , 86 (2) pp. 161-166. 10.1016/0304-3940(88)90564-2.

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Abstract

The cutaneous afferent volley on the dorsal root was recorded in normal rat pups and in pups whose fine diameter afferents had been destroyed with capsaicin at birth. From postnatal day 2 (P2) it was possible to identify a long latency wave in the afferent volley that was reduced or absent in capsaicin treated pups and therefore attributable to A delta and C fibers. Despite this, no difference between the evoked activity of dorsal horn cells to electrical skin stimulation in normal and capsaicin treated rat pups could be detected at P2 or P5. Only at P9 was a clear long latency burst of spikes evoked in dorsal horn cells that was absent in capsaicin treated rats. The results support the idea that the postsynaptic activity evoked by small diameter A and C fibres in the rat dorsal horn in the first postnatal week is very immature.

Type: Article
Title: The development of activity evoked by fine diameter cutaneous fibres in the spinal cord of the newborn rat.
Location: Ireland
DOI: 10.1016/0304-3940(88)90564-2
Keywords: Action Potentials, Animals, Animals, Newborn, Axons, Capsaicin, Electric Stimulation, Neurons, Afferent, Rats, Reaction Time, Skin, Skin Physiological Phenomena, Spinal Cord
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/121657
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