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SERUM AMYLOID-P COMPONENT IN CHRONIC-RENAL-FAILURE AND DIALYSIS

NELSON, SR; TENNENT, GA; SETHI, D; GOWER, PE; BALLARDIE, FW; AMATAYAKULCHANTLER, S; PEPYS, MB; (1991) SERUM AMYLOID-P COMPONENT IN CHRONIC-RENAL-FAILURE AND DIALYSIS. CLIN CHIM ACTA , 200 (2-3) 191 - 199.

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Abstract

A normal reference interval for serum amyloid P component (SAP) concentration in the serum was established in 500 healthy adult individuals (274 women, 226 men), by electroimmunoassay calibrated with standards of highly purified, isolated SAP. The mass of SAP in these was determined from the extinction coefficient of SAP at 280 nm measured here precisely for the first time by spectrophotometry and cryogenic drying. The mean (SD, range) SAP concentration was significantly lower in women: 24 mg/l (8, 8-55), compared to 32 mg/l (7, 12-50) in men (P < 0.001). In renal insufficiency patients, 38 with chronic renal failure, 79 on hemodialysis and 66 on continuous ambulatory peritoneal dialysis, the mean values for SAP concentration were all significantly higher than normal (range of means, 39-59 mg/l in men and 35-42 mg/l in women), but did not correlate with serum creatinine, duration of dialysis or the presence of an acute phase response. The metabolism of SAP is thus altered in renal failure and is not normalized by dialysis, but it is not clear whether this is relevant to the pathogenesis of dialysis related arthropathy and amyloidosis.

Type: Article
Title: SERUM AMYLOID-P COMPONENT IN CHRONIC-RENAL-FAILURE AND DIALYSIS
Keywords: SERUM AMYLOID-P COMPONENT, AMYLOIDOSIS, RENAL FAILURE, HEMODIALYSIS, CONTINUOUS AMBULATORY PERITONEAL DIALYSIS, C-REACTIVE PROTEIN, AMBULATORY PERITONEAL-DIALYSIS, BETA-2-MICROGLOBULIN AMYLOIDOSIS, DEPOSITS, SAP, CHROMATIN, PATIENT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/121622
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