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FACTOR-V LEIDEN GENE MUTATION AND THROMBIN GENERATION IN RELATION TO THE DEVELOPMENT OF ACUTE STROKE

CATTO, A; CARTER, A; IRELAND, H; BAYSTON, TA; PHILIPPOU, H; BARRETT, J; ... GRANT, PJ; + view all (1995) FACTOR-V LEIDEN GENE MUTATION AND THROMBIN GENERATION IN RELATION TO THE DEVELOPMENT OF ACUTE STROKE. ARTERIOSCL THROM VAS , 15 (6) 783 - 785.

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Abstract

To determine the prevalence of the factor V Leiden gene mutation in relation to the phenotypes of cerebral infarction and cerebral hemorrhage, we studied 386 randomly selected cases of acute stroke and 247 control subjects. Factor V genotype was determined by amplification of a 267-bp sequence of exon/intron 10 of the factor V gene. Levels of prothrombin fragment F-1+2, a marker of thrombin generation, were determined in both acute and convalescent stroke and related to factor V genotype. Prothrombin fragment F-1+2, was assessed by using an enzyme-linked immunosorbent assay. Sixteen stroke cases (4.1%) were identified as having the mutation compared with 14 (5.6%) control subjects. Prothrombin fragment F-1+2, levels were estimated in 191 cases and found to be elevated both acutely and after 3 months, but they were not related to factor V genotype. Prothrombin fragment F-1+2 is elevated in acute stroke and requires further evaluation in relation to cerebrovascular disease. These results suggest that the factor V Leiden gene mutation is not a risk factor for arterial thrombosis causing stroke.

Type:Article
Title:FACTOR-V LEIDEN GENE MUTATION AND THROMBIN GENERATION IN RELATION TO THE DEVELOPMENT OF ACUTE STROKE
Keywords:FACTOR V MUTATION, PROTHROMBIN F-1+2, STROKE, POOR ANTICOAGULANT RESPONSE, ACTIVATED PROTEIN-C, THROMBOPHILIA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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