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Kainate receptors with a metabotropic modus operandi

Rodriguez-Moreno, A; Sihra, TS; (2007) Kainate receptors with a metabotropic modus operandi. TRENDS NEUROSCI , 30 (12) 630 - 637. 10.1016/j.tins.2007.10.001.

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Abstract

Kainate receptors (KARs), together with AMPA and NMDA, are typically described as ionotropic glutamate receptors. The functions of KARs have begun to be elucidated only in the last decade. Although some the actions of KARs are classically ionotropic, surprisingly others seem to involve the activation of second-messenger cascades and invoke metabotropic roles for this type of glutamate receptor. In this review, we describe these metabotropic actions of KARs in relation to the putative signalling cascades involved. Although it is still a mystery how KARS activate G proteins to stimulate second-messenger cascades, intriguingly, in very recent studies, specific subunits of KARs have been demonstrated to associate with G proteins. Altogether, the body of evidence supports the hypothesis that, together with the canonical ionotropic operation, KARS expedite long-lasting signalling by novel metabotropic modes of action.

Type: Article
Title: Kainate receptors with a metabotropic modus operandi
DOI: 10.1016/j.tins.2007.10.001
Keywords: MOSSY-FIBER SYNAPSES, EXCITATORY SYNAPTIC-TRANSMISSION, MEDIATED PRESYNAPTIC INHIBITION, LONG-TERM DEPRESSION, PROTEIN-KINASE-A, GLUTAMATE RELEASE, RAT HIPPOCAMPUS, CORTICAL-NEURONS, PYRAMIDAL CELLS, GOLDFISH BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/120665
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