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DIFFERENTIAL REGULATION OF CYTOKINE PRODUCTION BY NITRIC-OXIDE

MARCINKIEWICZ, J; CHAIN, BM; (1993) DIFFERENTIAL REGULATION OF CYTOKINE PRODUCTION BY NITRIC-OXIDE. IMMUNOLOGY , 80 (1) 146 - 159.

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Abstract

Nitric oxide (NO) has recently been identified as a potent and pleiotropic intracellular mediator produced by and acting on many cells of the body. Although considerable attention has been devoted to the regulation of NO by inflammatory cytokines, and also to the role of NO as an important effector molecule in immune function, there is very little information on the role of this mediator in modulating T-cell-dependent cytokine production. In this study we show that physiological levels of NO (either produced by activated macrophages or by the addition of exogenous NO donors) can selectively down-regulate interleukin-3 (IL-3) production by spleen cells from contact-sensitized mice, while leaving IL-2 activity unaffected. Thus NO may have an important role as an immunomodulatory as well as effector molecule in the immune system.

Type: Article
Title: DIFFERENTIAL REGULATION OF CYTOKINE PRODUCTION BY NITRIC-OXIDE
Keywords: L-ARGININE, T-CELLS, MACROPHAGES, ACTIVATION, INVITRO, METABOLISM, SYNTHASE, PATHWAY, INVIVO, IL-2
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/120518
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