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A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos

Dale, L; Wardle, FC; (1999) A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos. SEMIN CELL DEV BIOL , 10 (3) 319 - 326.

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Abstract

BMP-4 is an extracellular signalling molecule belonging to the TGF-P superfamily that plays a central role in dorsoventral patterning in vertebrate gastrulae. We review the evidence indicating that BMP-4 acts as a morphogen, specifying dorsoventral positional values in concentration-dependent manner. An activity gradient of BMP-4 is established not by Simple diffusion from a localised source, but by diffusion of inhibitory binding proteins that act on a uniform level of BMP-4 protein. These in turn are regulated by the activity of tolloid-related metalloproteases, such as Xenopus xolloid and zebrafish tolloid.

Type: Article
Title: A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos
Keywords: BMP-4, chordin, noggin, mesoderm, Tld, Xenopus, BONE MORPHOGENETIC PROTEIN-4, SPEMANN ORGANIZER, DROSOPHILA EMBRYO, NEURAL INDUCTION, MARGINAL ZONE, PATTERN-FORMATION, DIRECT BINDING, MESODERM, ZEBRAFISH, NOGGIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/120434
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