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Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

Duchen, MR; (1999) Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J PHYSIOL-LONDON , 516 (1) 1 - 17.

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Abstract

Over recent years, it has become clear that mitochondria play a central role in many key aspects of animal physiology and pathophysiology. Their central and ubiquitous task is clearly the production of ATP. Nevertheless, they also play subtle roles in glucose homeostasis, acting as the sensor for substrate supply in the transduction pathway that promotes insulin secretion by the pancreatic beta-cell and that modulates the excitability of the hypothalamic glucose-sensitive neurons involved in appetite control. Mitochondria may also act as sensors of availability of oxygen, the other major mitochondrial substrate, in the regulation of respiration. Mitochondria take up calcium, and the high capacity mitochondrial calcium uptake pathway provides a mechanism that couples energy demand to increased ATP production through the calcium-dependent upregulation of mitochondrial enzyme activity. Mitochondrial calcium accumulation may also have a substantial impact on the spatiotemporal dynamics of cellular calcium signals, with subtle differences of detail in different cell types. Recent work has also revealed the centrality of mitochondrial dysfunction as an irreversible step in the pathway to both necrotic and apoptotic cell death. This review looks at recent developments in these rapidly evolving areas of cell physiology in an attempt to draw together disparate areas of research into it common theme.

Type: Article
Title: Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death
Keywords: PERMEABILITY TRANSITION PORE, SENSITIVE POTASSIUM CHANNELS, PANCREATIC BETA-CELLS, ROOT GANGLION NEURONS, RAT CAROTID-BODY, I CELLS, CYCLOSPORINE-A, K+ CHANNELS, ENDOPLASMIC-RETICULUM, HYPOTHALAMIC NEURONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/120423
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