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Sequences of monoclonal antiphospholipid antibodies: Variations on an anti-DNA antibody theme

Rahman, A; Menon, S; Latchman, DS; Isenberg, DA; (1996) Sequences of monoclonal antiphospholipid antibodies: Variations on an anti-DNA antibody theme. SEMIN ARTHRITIS RHEU , 26 (2) 515 - 525.

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Abstract

Antiphospholipid antibodies (aPL) are recognized increasingly as a probable cause of clinical features such as thrombosis and recurrent miscarriages, particularly in a subset of patients with systemic lupus erythematosus (SLE) and those with the antiphospholipid antibody syndrome (APS). A powerful method of studying the origin of these antibodies and delineating their binding sites is to sequence monoclonal aPL. The few reports of mouse aPL sequences suggest that gene families J558 and V(K)23 may be used preferentially but without extensive mutation of complementarity determining regions (CDR), Polyreactive human aPL, which bind DNA as well as phospholipids, generally use germline genes with few mutations. Specific immunoglobulin (Ig) M aPL also tend to use relatively unmutated genes but often have high concentrations of positive residues in CDR, which may enhance binding to anionic phospholipids. IgG aPL show many more antigen-selected mutations, particularly in heavy chain CDR. This difference between isotypes is similar to that seen in anti-DNA antibodies, but the role of positively charged residues in aPL is less evident, and additional motifs are likely to be important in antigen binding. Copyright (C) 1996 by W.B. Saunders Company

Type: Article
Title: Sequences of monoclonal antiphospholipid antibodies: Variations on an anti-DNA antibody theme
Keywords: antiphospholipid, sequence, monoclonal, SYSTEMIC LUPUS-ERYTHEMATOSUS, VARIABLE REGION GENES, SINGLE-STRANDED-DNA, LPR LPR MICE, ANTICARDIOLIPIN ANTIBODIES, B-CELLS, HEAVY, AUTOANTIBODIES, REPERTOIRE, SEGMENTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
URI: http://discovery.ucl.ac.uk/id/eprint/120411
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