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AN INTRACELLULAR 50-KDA FC-GAMMA-BINDING PROTEIN IS INDUCED IN HUMAN-CELLS BY ALPHA-IFN

THOMAS, NSB; LINCH, DC; (1991) AN INTRACELLULAR 50-KDA FC-GAMMA-BINDING PROTEIN IS INDUCED IN HUMAN-CELLS BY ALPHA-IFN. J IMMUNOL , 146 (5) 1649 - 1654.

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Abstract

This report describes a novel intracellular Ig Fc-binding protein that is induced by alpha-IFN in a wide range of human cell types. The protein has a m.w. of 45,000 to 50,000 and it will bind human IgG but not IgM, IgA, or IgE. The IgG-binding specificity of this protein (designated Fc-gamma-BP) is similar to that of the Fc-gamma-RII receptor in that it binds only to mouse IgG1 and IgG2b but not IgG2a. It is an intracellular protein and is detectable by immunoprecipitation from [S-35]methionine-labeled cells but it is undetectable on the cell surface. Fc-gamma-BP is a phosphoprotein, and the amount of phosphorylated Fc-gamma-BP increases after treatment with alpha-IFN. Although the function of this protein has yet to be determined, the induction of an Fc-binding protein by alpha-IFN suggests a role in the immune response, particularly during infection by viruses.

Type: Article
Title: AN INTRACELLULAR 50-KDA FC-GAMMA-BINDING PROTEIN IS INDUCED IN HUMAN-CELLS BY ALPHA-IFN
Keywords: MACROPHAGE FC-RECEPTORS, ACTIVATION, INTERFERON, IGG
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/120406
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