UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Continuous measurement of cerebral oxygenation by near infrared spectroscopy curing induction of anesthesia

Lovell, AT; Owen-Reece, H; Elwell, CE; Smith, M; Goldstone, JC; (1999) Continuous measurement of cerebral oxygenation by near infrared spectroscopy curing induction of anesthesia. ANESTH ANALG , 88 (3) 554 - 558.

Full text not available from this repository.

Abstract

Near infrared spectroscopy (NIRS) measures tissue oxygenation continuously at. the bedside, Major disturbances of cerebral oxygenation can be detected by using NIRS, but the ability to observe smaller changes is poorly documented. Although anesthetics generally depress cerebral metabolism and enhance oxygen delivery, the administration of etomidate has been associated with cerebral desaturation. We used this difference to study the ability of NIRS to detect the small changes associated, with the onset of anesthesia. Thirty-six healthy patients were randomly allocated to have anesthesia induced with either etomidate, propofol, or thiopental. We found that there was a temporal association between the onset of anesthesia and NIRS-derived indices of cerebral oxygenation. Etomidate was associated with a decrease in cerebral oxygenation, whereas propofol and thiopental were associated with an increase in cerebral oxygenation. We conclude that NIRS is capable of detecting the small changes in cerebral oxygenation associated with the induction of general anesthesia and shows promise as a bedside investigational tool for the noninvasive assessment of cerebral oxygenation. Implications: We conclude that near infrared spectroscopy is capable of detecting the small changes in cerebral oxygenation associated with the induction of general anesthesia and shows promise as a bedside investigational tool for the noninvasive assessment of cerebral oxygenation.

Type: Article
Title: Continuous measurement of cerebral oxygenation by near infrared spectroscopy curing induction of anesthesia
Keywords: BLOOD-VOLUME, CAROTID ENDARTERECTOMY, VOLUNTEERS, METABOLISM, TOMOGRAPHY, ETOMIDATE, ISCHEMIA, HEAD, NIRS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/120398
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item