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Regulation of bone resorption and formation by purines and pyrimidines

Hoebertz, A; Arnett, TR; Burnstock, G; (2003) Regulation of bone resorption and formation by purines and pyrimidines. TRENDS PHARMACOL SCI , 24 (6) 290 - 297. 10.1016/S0165-6147(03)00123-8.

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Abstract

Growing evidence suggests that extracellular nucleotides, signalling through P2 receptors, might play important roles in the regulation of bone and cartilage metabolism. ATP and other nucleotides can exert impressive stimulatory effects on the formation and activity of osteoclasts (bone-resorbing cells) in addition to inhibiting bone formation by osteoblasts. In this review, the current understanding of the actions of nucleotides on skeletal cells and the probable receptor subtypes involved are discussed.

Type: Article
Title: Regulation of bone resorption and formation by purines and pyrimidines
DOI: 10.1016/S0165-6147(03)00123-8
Keywords: HUMAN ARTICULAR CHONDROCYTES, BOVINE NASAL CARTILAGE, OSTEOBLAST-LIKE CELLS, EXTRACELLULAR ATP, NUCLEOTIDE RECEPTORS, NONSELECTIVE CATION, SYSTEMIC RESPONSES, RABBIT OSTEOCLASTS, CYTOSOLIC CALCIUM, RAT OSTEOBLASTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/120037
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