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Selective expression of purinoceptor cP2Y(1) suggests a role for nucleotide signalling in development of the chick embryo

Meyer, MP; Clark, JDW; Patel, K; Townsend-Nicholson, A; Burnstock, G; (1999) Selective expression of purinoceptor cP2Y(1) suggests a role for nucleotide signalling in development of the chick embryo. DEV DYNAM , 214 (2) 152 - 158.

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Abstract

Responses to extracellular nucleotides (e.g,, ATP, ADP, etc.) have been demonstrated in a number of embryonic cell types suggesting they may be important signalling molecules during embryonic development. Here the authors describe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y(1) (cP2Y(1)), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y(1) is expressed in a developmentally regulated manner in the limb buds, mesonephros, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems, Dev Dyn 1999;214:152-158. (C) 1999 Wiley-Liss, Inc.

Type: Article
Title: Selective expression of purinoceptor cP2Y(1) suggests a role for nucleotide signalling in development of the chick embryo
Keywords: ATP, chick embryo, P2Y receptors, PRIMARY CULTURES, TRANSDUCTION PATHWAY, EXTRACELLULAR ATP, GROWTH-FACTORS, RAT STRIATUM, ASTROCYTES, PROLIFERATION, ANALOGS, ADENOSINE, RECEPTORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/119605
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