UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Treating leprosy: an Erb-al remedy?

Noon, LA; Lloyd, AC; (2007) Treating leprosy: an Erb-al remedy? TRENDS PHARMACOL SCI , 28 (3) 103 - 105. 10.1016/j.tips.2007.01.004.

Full text not available from this repository.

Abstract

The leprosy pathogen Mycobacterium leprae attacks Schwann cells in the peripheral nervous system, causing them to demyelinate. Recent work by Tapinos et ah shows that a direct mechanism of demyelination induced by M. leprae depends on the binding of the bacterium to the receptor tyrosine kinase ErbB2 on Schwann cells and the resulting activation of the Ras-Raf-MEK-ERK pathway. These findings have relevance for the potential treatment of leprosy and they highlight parallels between the dedifferentiation signal in leprosy and that in nerve injury and cancer.

Type: Article
Title: Treating leprosy: an Erb-al remedy?
DOI: 10.1016/j.tips.2007.01.004
Keywords: MYCOBACTERIUM-LEPRAE, DEMYELINATION, PROLIFERATION, DEGENERATION, INSIGHTS, BACILLI, PATHWAY, CELLS
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/119498
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item